Volume 3, Issue 2 (9-2015)
Clin Exc 2015, 3(2): 1-14 |
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Abstract: (14581 Views)
The genus Salvia from the Lamiaceae family has numerous different species - a bout 900 species, which are extensively distributed in various regions of the world. Species such as S.urmiensis, S. sahendica, Salvia hypoleuca and S. persepolitana are native of Iran. Many Salvia species are well-studied and widely used in traditional medicine. This Plant contains the wide variety of secondary metabolites, such as flavonoids, tannins and terpenoids.The terpenoid class, extracted from Salvia, includes a wide range of mono-di-, tri-, sesqui- and tetraterpenoids. Many diterpenoids and triterpenoids, isolatedfrom plants of several species of the genus Salvia, have been investigated for theirpharmacological activities: analgesic anti-inflammatory hemostatic antioxidant antimicrobial and as an antitumoral remedy. It has been widely shown that manyterpenoid compounds have significant anti-inflammatory effects. For this reason, theyare potential molecules for the development of new drugs especially designed for thetreatment and/or control of chronic inflammatory states such as rheumatism, asthma, inflammatory bowel diseases, atherosclerosis, etc. Some di- and triterpens from Salvia ssp are able to influence the central nervous system (CNS). S. limbataand S. hypolecuca extracts produced statistically significant inhibition of pain and development of morphine dependence in mice. Results of the present study showed that the aqueous methanolic extract of the aerial parts (flowered browse at 1000 mg kg-1) of S.limbata produced a statistically significant produced inhibition of pain and development of morphine dependence in mice, in comparison with the control
Type of Study: Review |
Subject:
شیمی دارویی
Received: 2015/03/1 | Accepted: 2015/03/1 | Published: 2015/03/1
Received: 2015/03/1 | Accepted: 2015/03/1 | Published: 2015/03/1
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