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Zarinfar N, Alizadeh M, Ahrari K, Rahimi A, Farahi F, Zarinfar Y. Review of Effect of Underlying diseases and demographic factors on mortality rate Covid19. Clin Exc 2021; 11 (S2) :76-90
URL: http://ce.mazums.ac.ir/article-1-674-en.html

The today s most concerning problem in the world is the morbidity and mortality following covid19 infection. The aim of this study is to investigate different factors and their impacts on mortality rate of covid19 patients.
 In this review article, recent studies from February 2019 to April 2021 were assessed using English and Persian resources. The keywords were Covid19, mortality rate, underlying diseases, and demographic factors which were investigated through PubMed, Web of Science, Science Direct, Iran Medex, Ovid, Scopus, Scientific information database and Magi ran. At first 298 articles were collected. Then titles and abstracts were assessed. Due to inclusive, exclusive criteria, and aims of research, 51 articles were selected and entered to the study. Underlying diseases like hypertension, cardiovascular diseases, diabetes, and obesity could lead to the increase of covid19 complications and mortality by weakening the immune system, producing inflammation, inducing metabolic disorders, coagulopathy, and impairing respiratory system function. Demographic factors like age, sex, race and occupation could affect mortality rate of covid19 patients due to physiologic differences, rate of contacts, and protection measures. The impact of life-style on covid19 complications and mortality and preventing measures needed for modifications could be of high-interest in the future studies.