Volume 2, Number 1 (3-2014)                   Clin Exc 2014, 2(1): 99-115 | Back to browse issues page


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Rafatmanesh A, Abedian- kenari S, Ghaffari J. Allergic asthma and transcription factors “Tbet, Gata3”. Clin Exc . 2014; 2 (1) :99-115
URL: http://ce.mazums.ac.ir/article-1-85-en.html

Abstract:   (15579 Views)

  Asthma is a chronic inflammatory disease characterized by eosinophil ic inflammation and airflow obstruction. More than 300 million people suffer from this disease and its prevalence is increasing. Common symptoms of asthma are wheezing , coughing and shortness of breath . Many studies have shown that T cell activity can be related by severity of asthma , degree of narrowing of airways and eosinophil response . The atopic individuals with asthma, immune response are mainly Th2 (T helper) type while the non- atopic individuals are predominantly Th1 (T helper1) type . Th2 immune response is associated with increased interleukin 4, 5 and 13 that will be found more frequently in patients with asthma. Immune response with excellence Th1 is abundance INF- g and IL-2. An imbalance between Th1 and Th2 got involved in atopic and asthma diseases . Specific transcription factors such as T-bet and GATA-3 is involved in the differentiation of TH0 to Th1 and Th2 . GATA-3 is a transcription factor that regulates the expression of Th2 . In contrast, T-bet regulates the differentiation of Th1 . These expression factors regulate Th1/Th2 balance and allergic response . This paper is an overview of asthma , associated genes, and new treatment and prevention methods based on T-bet and GATA-3.

Keywords: Asthma, GATA-3, T-bet
Full-Text [PDF 846 kb]   (1418 Downloads)    
Type of Study: Review | Subject: آسم و آلرژی کودکان
Received: 2014/01/10 | Accepted: 2014/02/17 | Published: 2014/03/17

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