TY - JOUR T1 - A Review of the Role of Statins in the Treatment of Heart Failure with the Emphasis on the Oxidative Stress TT - مروری بر نقش استاتین ها در درمان نارسایی قلبی با تأکید بر استرس اکسیداتیو JF - Clinical-Excellence JO - Clinical-Excellence VL - 1 IS - 1 UR - http://ce.mazums.ac.ir/article-1-31-en.html Y1 - 2013 SP - 113 EP - 128 KW - Statin KW - Atherosclerosis KW - heart failure KW - oxidative J N2 - Cholesterol reduction by statins improves the survival of patients with the atherosclerotic cardiovascular diseases, though serum cholesterol level is normal or borderline. In some studies, statins have been administered to the heart failure patients irrespective of their atherosclerosis state or LDL-levels. Statins may have favorable effects on the oxidative stress and the cardiac remodeling process. Due to the contradictory results of the studies, this review will briefly discuss the role of oxidative stress and inflammation in the heart failure, and then the effects of statins on the inflammatory mediators involved in the heart failure and the clinical trials assigned to the role of statins in the management of heart failure. Finally, considering the methodology of clinical trials, recommendations regarding the use of statins in heart failure patients will be presented. M3 ER -