Clinical Excellence
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Clin Exc
Medical Sciences
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مروری بر نئوپلازی سنگفرشی سطح چشم در افراد مبتلا به HIV
A review of ocular surface squamous neoplasia in people with HIV
بیماریهای چشم
بیماریهای چشم
مروری
Review
<div style="text-align: justify;"> <span style="color:#231F20;"><span style="font-family:b zar;">نئوپلازی سنگفرشی سطح چشم</span></span><span style="color:#231F20;"><span style="font-family:b zar;"><span style="font-size:10.0pt;">(</span></span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">OSSN</span></span></span></span><span style="color:#231F20;"><span style="font-family:b zar;"><span style="font-size:10.0pt;">)</span></span></span><span style="color:#231F20;"><span style="font-family:b zar;"> به طیف وسیعی از تومورهای اپیتلیال ملتحمه و قرنیه شامل دیسپلازی، کارسینوما درجا و سرطان تهاجمی اشاره دارد. افزایش بروز </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">OSSN</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">با ویروس نقص ایمنی انسانی</span></span><span style="color:#231F20;"><span style="font-family:b zar;"><span style="font-size:10.0pt;">(</span></span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">HIV</span></span></span></span><span style="color:#231F20;"><span style="font-family:b zar;"><span style="font-size:10.0pt;">)</span></span></span><span style="color:#231F20;"><span style="font-family:b zar;"> به دلیل عوامل خطر مرتبط با آن، مانند ویروس پاپیلومای انسانی و قرار گرفتن در معرض نور ماوراءبنفش خورشید قابلملاحظه است. در این مرور، اپیدمیولوژی، تظاهرات بالینی، نحوه تشخیص و درمان </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">OSSN</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">مرتبط با عفونت </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">HIV</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">را موردبحث قرار میدهیم. جستجوی</span></span> <span style="color:#231F20;"><span style="font-family:b zar;">الکترونیک</span></span> <span style="color:#231F20;"><span style="font-family:b zar;">با کلیدواژههای</span></span> <span style="color:#231F20;"><span style="font-family:b zar;">لاتین</span></span> <span style="color:#231F20;"><span style="font-family:b zar;">شامل: </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">Acquired Immune Deficiency Syndrome</span></span></span></span> <span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">(AIDS), Eye Surface, Squamous Neoplasia, Human Immunodeficiency Virus (HIV)</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">در پایگاه دادههای </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">Google Scholar, Elsevier, Pubmed, ISI (Web of Science), Iran Medex, Scopus</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">با زبان انگلیسی از سال </span></span><span style="color:#231F20;"><span style="font-family:b zar;"><span style="font-size:10.0pt;">2018-1992 </span></span></span><span style="color:#231F20;"><span style="font-family:b zar;">استفاده شد. </span></span><span style="color:#231F20;"><span style="font-family:b zar;"><span style="font-size:10.0pt;">101 </span></span></span><span style="color:#231F20;"><span style="font-family:b zar;">مقاله مرتبط از طریق جستجو شناساییشدهاند، در این مرور،</span></span> <span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">OSSN</span></span></span></span><span style="color:#231F20;"><span style="font-family:b zar;">بهعنوان اولین نشانگر </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">HIV/AIDS</span></span></span></span><span style="color:#231F20;"><span style="font-family:b zar;"> در </span></span><span style="color:#231F20;"><span style="font-family:b zar;"><span style="font-size:10.0pt;">86 -26</span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">درصد موارد گزارششده است، تست مثبت </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">HIV</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">در </span></span><span style="color:#231F20;"><span style="font-family:b zar;"><span style="font-size:10.0pt;">92 -38</span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">درصد بیماران با </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">OSSN</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">ذکر شده است. سن متوسط بروز </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">OSSN</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">در بیماران مبتلا به </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">HIV</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">در کشورهای درحالتوسعه به دهه سوم تا چهارم کاهشیافته است. مبتلایان به ویروس </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">HIV</span></span></span></span><span style="color:#231F20;"><span style="font-family:b zar;">، تومورهای تهاجمی بزرگتر، بدخیمی شدیدتر، تهاجم قرنیهای، اسکلرال و اربیتال بیشتر، تومورهایی با مرحله پیشرفته<sub>­</sub>تر</span></span><span style="color:#231F20;"><span style="font-family:b zar;"><span style="font-size:10.0pt;">(</span></span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">T4</span></span></span></span><span style="color:#231F20;"><span style="font-family:b zar;"><span style="font-size:10.0pt;">)،</span></span></span><span style="color:#231F20;"><span style="font-family:b zar;"> نیاز بیشتر به تخلیه و وسیعتر و افزایش خطر عود مجدد تومور را نشان دادهاند. قابلتوجه است که مدیریت فعلی </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">OSSN</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">در افراد دارای </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">HIV</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">مثبت مبتنی بر همان دستورالعملهای استاندارد درمانی است که برای </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">OSSN</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">در عموم جامعه شرح دادهشده است. اغلب مطالعات نشان دادند که </span></span> <span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">OSSN</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">میتواند در هر زمانی از دوره بیماری </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">HIV/AIDS</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">رخ دهد و هیچ ارتباط قابلتوجهی بین تعداد </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">CD4</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">و درجه </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">OSSN</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">پیدا نشده است. علاوه بر این، تأثیر درمان ضد رتروویروس بر </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">OSSN</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">بحث<sub>­</sub>برانگیز است. براساس شواهد موجود غربالگری </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">HIV</span></span></span></span><span style="color:#231F20;"><span style="font-family:b zar;"> در کلیه موارد همراه با </span></span><span dir="LTR"><span style="color:#231F20;"><span style="font-family:advot1ef757c0;"><span style="font-size:10.0pt;">OSSN</span></span></span></span> <span style="color:#231F20;"><span style="font-family:b zar;">توصیه میشود. اهمیت بیماری و خطر عود و گسترش آن به بیماران با تأکید بر پیگیری منظم و مراجعه بهنگام به چشمپزشک برای هرگونه علائم نامشخص چشمی گوشزد گردد. </span></span></div>
<div style="text-align: justify;"> Ocular surface squamous cell neoplasia (OSSN) refers to a wide range of conjunctival and corneal epithelial tumors including: dysplasia, in situ carcinoma, and invasive cancer. The incidence of OSSN with human immunodeficiency virus (HIV) is increased due to its associated risk factors, such as human papillomavirus and exposure to sunlight. In this review, we discuss the epidemiology, clinical presentation, diagnosis, and treatment of OSSN associated with HIV infection. A search of the Google Scholar, Elsevier, Pubmed, ISI (Web of Science), Iran Medex, Scopus database in English from 1992 to 2018 was used to investigate the prevalence and prevalence of HIV positive squamous cell neoplasia. Eligibility criteria include any type of study that addresses the clinical manifestations of OSSN according to HIV status. Cases involving or screening for other types of malignancies in other groups were excluded. The 101 articles identified through the search were, in this review, OSSN reported as the first HIV / AIDS marker in 26 -86% of cases, and HIV positive testing in 38 -92% of patients with OSSN listed. The median age of onset of OSSN in HIV-infected patients in developing countries has dropped to the third to fourth decade. Those infected with HIV have shown larger invasive tumors, more severe malignancy, more invasive corneal, scleral and orbital invasion; more advanced stage tumors (T4), greater need for enucleation and wider exentration, and increased risk of tumor recurrence. It is noteworthy that current management of OSSN in HIV-positive people is based on the same standard treatment guidelines as described for OSSN in the general population. Most studies have shown that OSSN can occur at any time during the HIV / AIDS courses, and no significant association was found between CD4 count and severity of OSSN. In addition, the impact of antiretroviral treatment on OSSN is controversial. Based on the available evidence, HIV screening is recommended in all cases associated with OSSN to rule out HIV infection. The importance of the disease and the risk of relapse and its spread to patients should be counseled, with emphasis on regular follow-up and timely referral to the ophthalmologist for any unspecified ocular symptoms.</div>
سندرم نقص ایمنی اکتسابی, نئوپلازی, سنگفرشی, سطح چشم, ویروس نقص ایمنی انسانی.
Cognitive Behavior Therapy, Development, Children. Acquired Immune Deficiency Syndrome (AIDS), Eye Surface, Squamous Neoplasia, Human Immunodeficiency Virus (HIV).
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http://ce.mazums.ac.ir/browse.php?a_code=A-10-97-3&slc_lang=fa&sid=1
Amir
Ahmadzadeh Amiri
امیر
احمدزاده امیری
Amir.amzd93@gmail.com
10031947532846002829
10031947532846002829
No
Tehran Medical School, Tehran University of Medical Sciences
دانشگاه علوم پزشکی تهران، ایران.
Fatemeh
Daneshvar
فاطمه
دانشور
daneshvar.f67@gmail.com
10031947532846002830
10031947532846002830
No
Sari Behavioral Disease Counseling Center, Mazandaran University Faculty of Medicine
مرکز مشاوره بیماریهای رفتاری شهرستان ساری، دانشگاه علوم پزشکی مازندران، مازندران، ایران.
Ali
Ahmadzadeh Amiri
علی
احمدزاده امیری
Ali_ahmdzdh@yahoo.com
10031947532846002831
10031947532846002831
No
Tehran Medical School, Tehran University of Medical Sciences
دانشگاه علوم پزشکی تهران، ایران.
Ahmad
Ahmadzadeh Amiri
احمد
احمدزاده امیری
Ahmadzdh@yahoo.com
10031947532846002832
10031947532846002832
Yes
Department Ophthalmology, Bu Ali Hospital, Faculty of Medicine, Mazandaran
دانشکده پزشکی، دانشگاه علوم پزشکی مازندران