Inflammation is as a beneficial response to injury on the other hand, inflammation is accounted as complex immune systems of the host against agents biologic, chemical and physical. Chronic inflammation that was produced by genetic mutations, autoimmune diseases and environments factors can increase risk of cancer. Epidemiologic studies have shown more than 25% of dead cause of cancer was inflammation. Although, today it is believed that inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury and that the basic signs of inflammation can be explained by pain, increased blood flow, red and swelling. Acute inflammation can be produced in which under normal conditions is considered as immune reaction, if it converted to chronic inflammation can be led to cancer, CVD, lung and nervous diseases. The aim of the present minireview was to examine the evidence about inflammation and its correlation with cancer.