Volume 1, Issue 1 (winter 2013)
Clin Exc 2013, 1(1): 44-63 |
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Zakaryaee V, Hosseinimehr S J. Supplement antioxidant administration during radiotherapy in cancer, yes or no?. Clin Exc 2013; 1 (1) :44-63
URL: http://ce.mazums.ac.ir/article-1-27-en.html
URL: http://ce.mazums.ac.ir/article-1-27-en.html
Abstract: (11549 Views)
Radiotherapy is widely used for cancer treatment. In radiotherapy, free radicals and other
reactive oxygen species are produced when they are passed through cells. These free radicals
can interact with critical macromolecules such as DNA which is led to cell toxicity and
death.
Radioprotective agents and antioxidant supplements can scavenge free radicals and protect
cells against toxicity induced by these toxic substances. Although free radicals produced by
radiotherapy are necessary for cancer treatment, they are toxic for normal cells. It is a paradoxical
effect for antioxidant as a protective agent in normal cells or tumor cells. It is the main problem
of antioxidant co-administration in patients during radiotherapy.
After reviewing clinical trials and systematic reviews about efficacy of antioxidants to
reduce side effects induced by radiotherapy in patients, it was found that antioxidant
supplements improved average survival rate and reduced side effects induced by radiotherapy.
Further clinical trials for more evidence for selection of antioxidant, dosage and duration of
administration are needed.
Keywords: Antioxidant,
Subject:
اپيدميولوژي
Received: 2013/01/13 | Accepted: 2013/08/27 | Published: 2013/08/27
Received: 2013/01/13 | Accepted: 2013/08/27 | Published: 2013/08/27
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