Volume 6, Issue 2 (5-2017)                   Clin Exc 2017, 6(2): 49-62 | Back to browse issues page

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Mohammadi K, Zeinalzadeh N, Safaralizadeh R. An overview on the molecular basis of anticancer effects of Rosa canina bioactive ingredients. Clin Exc 2017; 6 (2) :49-62
URL: http://ce.mazums.ac.ir/article-1-351-en.html
Department of Animal Biology, faculty of Natural Science, University of Tabriz, Tabriz, Iran.
Abstract:   (4913 Views)
Doge rose with scientific name Rosa canina is a medicinal plant, shrub and perennial related to Rosaceae family. Its origin is different regions of Europe, Asia, and America and as well as north and northwest of Iran. There are several medicinal ingredients in different parts of this plant especially in its hips and seeds which introduced it as one of the important medicinal plants. This plant is famous for having vitamin C, antioxidants and anti-inflammatory properties and is used for curing various illnesses such as joint inflammation. Different researches were conducted on Rosa canina confirmed the presence of several bioactive ingredients other than vitamin C. The most important of them are triterpene acids, fatty acids, Galactolipids, Flavonoids and Phytosterols. Extract of this plant and its bioactive ingredients exhibit anticancer properties so that inhibit growths and extension of cancerous cells to other areas. They have a modulating effect on expression of genes and signaling pathways involved in cancer. On the other hand, they have inhibitory effects on function of oncogenes and inflammation processes and block migration of tumor cells to other tissues by inhibition of metastasis especially with antiangiogenic activities. The mentioned ingredients have positive effects on tumor suppressor genes, cell cycle checkpoints, immune system and stimulate programmed cell death in cancer cells. In this review we searched three bibliographic databases, PubMed, Google scholar and Scopus, to evaluate the anticancer properties of Rosa canina at the molecular level.
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Type of Study: Review | Subject: تغذيه
Received: 2017/02/19 | Accepted: 2017/05/12 | Published: 2017/05/12

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