Volume 12, Issue 2 (10-2022)                   Clin Exc 2022, 12(2): 1-10 | Back to browse issues page

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Sadeghi P, Ziaee V, Parvaneh N. A look at autoinflammatory disorders: A new area with rapid expansion in Pediatrics. Clin Exc 2022; 12 (2) :1-10
URL: http://ce.mazums.ac.ir/article-1-722-en.html
Children's Medical Center Hospital, Tehran university of medical sciences, Tehran, Iran.
Abstract:   (1260 Views)
Autoinflammatory diseases include conditions resulting from abnormal innate immune system activity, persistent or periodic attacks of inflammation occur, and lack of high titers of specific antibodies. The genetic background has played an essential role in their occurrence, and their gradual identification has provided the basis for a faster diagnosis of the disease. Recurrent or persistent fever attacks are the main feature of these disorders. In addition, inflammation of various systems such as skin, serous membranes, joint and bone, and other organs is observed. Several treatments have been used to control inflammation, including non-steroidal anti-inflammatory drugs, corticosteroids and biological and non-biological immunomodulatory agents, which have been relatively successful in controlling diseases.
Chronic inflammation over the years can lead to the secretion of various substances in the body. With their deposition in multiple tissues, there is a possibility of systemic amyloidosis and organ failure in many of these diseases.
This group's most common two diseases in Iran are familial Mediterranean fever and Marshall syndrome. The late diagnosis of the first disease is associated with a high risk of amyloidosis, and Marshall syndrome can severely affect the child's and parents' quality of life.
 
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Type of Study: Review | Subject: روماتولوژی اطفال
Received: 2021/08/17 | Accepted: 2022/05/31 | Published: 2022/09/1

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