fa منیزیم و میگرن: مروری بر شواهد شیمی دارویی شیمی دارویی مروری Review <p align="justify" style="DIRECTION: rtl"><span lang="FA" style="FONT-FAMILY: "B Zar" FONT-SIZE: 12pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">میگرن یک بیماری عصبی_- عروقی مغزی می باشد که </span><span lang="FA" style="FONT-FAMILY: "B Zar" FONT-SIZE: 10pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">6 </span><span lang="FA" style="FONT-FAMILY: "B Zar" FONT-SIZE: 12pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">درصد از مردان و </span><span lang="FA" style="FONT-FAMILY: "B Zar" FONT-SIZE: 10pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">18 </span><span lang="FA" style="FONT-FAMILY: "B Zar" FONT-SIZE: 12pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">درصد از زنان را در سراسر جهـان درگیر می_­کند. شواهد نشان می_­دهند که میگرن با کاهش سطح منیزیم در سرم همراه می_­باشد و همچنین دریافت آن می_­تواند علائم میگرن را کاهش دهد. هدف مطالعه_­ی حاضر، مروری بر پژوهش_­های انجام گرفته در زمینه ارتباط میگرن با منیزیم می_­باشد. </span><span lang="AR-SA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: AR-SA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">این مطالعه مروری با جستسجو در پایگاه_­های اطلاعاتی </span><span style="FONT-FAMILY: "Times New Roman","serif" COLOR: black FONT-SIZE: 10pt mso-bidi-language: AR-SA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">PubMed</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: AR-SA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"><span dir="rtl"></span><span dir="rtl"></span>،</span><span style="FONT-FAMILY: "Times New Roman","serif" COLOR: black FONT-SIZE: 10pt mso-bidi-language: AR-SA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">Scopus</span><span style="FONT-FAMILY: "Times New Roman","serif" COLOR: black FONT-SIZE: 12pt mso-bidi-language: AR-SA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US"> </span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"><span dir="rtl"></span><span dir="rtl"></span>،</span><span style="FONT-FAMILY: "Times New Roman","serif" COLOR: black FONT-SIZE: 10pt mso-bidi-language: AR-SA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">Science Direct </span><span dir="rtl"></span><span dir="rtl"></span><span style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 10pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"><span dir="rtl"></span><span dir="rtl"></span><span style="mso-spacerun: yes"><font face="B Zar" size="2"> </font></span></span><span lang="FA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">و</span><span style="FONT-FAMILY: "Times New Roman","serif" COLOR: black FONT-SIZE: 10pt mso-bidi-language: AR-SA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">Web of Science</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"><span dir="rtl"></span><span dir="rtl"></span> و</span><span lang="FA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: AR-SA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"> </span><span lang="AR-SA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: AR-SA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">با استفاده از کلیدواژه_­های: </span><span style="FONT-FAMILY: "Times New Roman","serif" COLOR: black FONT-SIZE: 10pt mso-bidi-language: AR-SA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">Migraine</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: AR-SA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="FONT-FAMILY: "Times New Roman","serif" COLOR: black FONT-SIZE: 10pt mso-bidi-language: AR-SA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">Headache</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: AR-SA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-bidi-language: AR-SA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">Magnesium</span><span dir="rtl"></span><span dir="rtl"></span><span lang="AR-SA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: AR-SA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"><span dir="rtl"></span><span dir="rtl"></span> و</span><span dir="ltr"></span><span dir="ltr"></span><span lang="AR-SA" style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 12pt mso-bidi-language: FA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US"><span dir="ltr"></span><span dir="ltr"></span> </span><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-bidi-language: FA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">Mg²⁺</span><span lang="AR-SA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: AR-SA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">صورت گرفت. در این مقاله مطالعات کارآزمایی بالینی، مقطعی، آینده_­نگر و گذشته_­نگر انتشار یافته بین سال­های 2014-1990 مورد بررسی قرار گرفتند. </span><span lang="FA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">مطالعاتی که میگرن را با معیارهای </span><span style="FONT-FAMILY: "Times New Roman","serif" COLOR: black FONT-SIZE: 10pt mso-bidi-language: FA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">IHS</span><span dir="rtl"></span><span dir="rtl"></span><span style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 10pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"><span dir="rtl"></span><span dir="rtl"></span> </span><span lang="FA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">تشخیص داده و بر روی انسان انجام شده بودند </span><span lang="AR-SA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: AR-SA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">وارد مطالعه شده و مقالاتی که به زبان غیر_­انگلیسی بودند و </span><span lang="FA" style="FONT-FAMILY: "B Zar" COLOR: black FONT-SIZE: 12pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">مطالعاتی که هدف اصلی آنها سردرد تنشی بود، از مطالعه خارج شدند.</span><span lang="FA" style="FONT-FAMILY: "B Zar" FONT-SIZE: 12pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"> در بیشتر مطالعات بررسی شده، سطح منیزیم در سرم در بیماران میگرنی پایین_­تر از افراد سالم بود. اما تفاوت معنی_­داری بین سطح سرمی منیزیم در میگرن با اورا (میگرن همراه با اختلالات بینایی) و بدون اورا مشاهده نشد. همچنین سطح منیزیم در حین حملات میگرنی و در بین آنها تفاوت معنی_­داری نداشت. در اکثر کارآزمایی_­های بالینی انجام شده، دریافت منیزیم باعث کاهش علائم میگرن از جمله شدت، فرکانس و طول مدت حملات میگرن شد. همچنین نیاز به داروهای ضدمیگرن نیز در این افراد کاهش یافت. البته دریافت منیزیم در برخی مطالعات منجر به بروز عوارضی از جمله اسهال و سوزش معده شد. </span></p> <span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-bidi-language: FA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">Migraine is a neurovascular disease that affects 6% of men and 18% of women worldwide. Evidences have shown that migraine is associated with a reduction in serum levels of magnesium, and also magnesium supplementation can decrease the migraine symptoms. This study aimed to review the available evidence in relation to migraine and magnesium.</span><span dir="rtl"></span><span dir="rtl"></span><span style="FONT-FAMILY: "B Zar" FONT-SIZE: 10pt mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"><span dir="rtl"></span><span dir="rtl"></span> </span><span style="FONT-FAMILY: "Times New Roman","serif" COLOR: black FONT-SIZE: 10pt mso-bidi-language: FA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">This review study was done by searching on PubMed, Scopus, Science Direct and Web of Science by entering “migraine”, “headache”, “</span><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-bidi-language: AR-SA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">magnesium</span><span style="FONT-FAMILY: "Times New Roman","serif" COLOR: black FONT-SIZE: 10pt mso-bidi-language: FA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">” and “</span><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-bidi-language: FA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">Mg²⁺<font size="2"><font face="Times New Roman"><span style="COLOR: black">” as keywords. In this study, clinical trial, cross-sectional, retrospective and prospective studies which were published during 1990 to 2014 were reviewed. We included studies that were diagnosed migraine based on IHS criteria and were done on human, and excluded non-English language articles and studies that investigated pulsating headaches as the main aim.</span> </font></font></span><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-bidi-language: AR-SA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">In most evaluated studies, migraine was associated with low serum levels of magnesium compared with healthy control. No significant difference was found</span><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-bidi-language: FA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US"> in magnesium levels</span><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-bidi-language: AR-SA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US"> between migraine with aura and without aura.</span><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-bidi-language: FA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US"> Also, </span><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-bidi-language: AR-SA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US">No significant difference was seen</span><span style="FONT-FAMILY: "Times New Roman","serif" FONT-SIZE: 10pt mso-bidi-language: FA mso-fareast-font-family: 'Times New Roman' mso-bidi-font-family: 'B Zar' mso-ansi-language: EN-US mso-fareast-language: EN-US"> within and between migraine attacks in this regard. In most clinical trials, magnesium supplementation revealed a reduction in severity, frequency and duration of migraine attacks. Furthermore, this supplementation decreased needs of medications in migraine patients significantly. However, in a few studies, magnesium intake had side effects such as diarrhea and stomach irritation.</span> میگرن, سردرد, منیزیم,+Mg2 Migraine, Headache, Magnesium, Mg2+. 15 27 http://ce.mazums.ac.ir/browse.php?a_code=A-10-26-25&slc_lang=fa&sid=1 Omid Sadeghi امید صادقی 1003194753284600747 1003194753284600747 No Morteza Nasiri مرتضی نصیری Mortezanasiri.or87@yahoo.com 1003194753284600748 1003194753284600748 Yes Fatemeh Allahyari Bayatiyani فاطمه الله یاری بیاتیانی 1003194753284600749 1003194753284600749 No Hamid Rasad حمید رسد 1003194753284600750 1003194753284600750 No Naseh Pahlavani ناصح پهلوانی 1003194753284600751 1003194753284600751 No Zahra Maghsoudi زهرا مقصودی 1003194753284600752 1003194753284600752 No Gholamreza Askari غلامرضا عسکری 1003194753284600753 1003194753284600753 No