Volume 6, Number 2 (5-2017)                   Clin Exc 2017, 6(2): 12-21 | Back to browse issues page


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Salehi Z, Agha Kuchak Afshari S, Rezaie S, Mahmodpour S, Khodavaisy S. A Review of Antimicrobial activity of flavonoids . Clin Exc . 2017; 6 (2) :12-21
URL: http://ce.mazums.ac.ir/article-1-310-en.html

Abstract:   (624 Views)

During the last decades, with increased mortality of immunocompromised patients due to increasing of antibiotic resistance in bacterial infections, needs essential affords to develop therapeutic agents with less toxicity, effectiveness and new mechanism of action. Therefore, usage of natural products such as flavonoids to treat microbial diseases have been increasingly developed. This paper will be an overview of the structural characteristics of flavonoids as well as the antimicrobial activity of new derivatives flavones against microbial pathogens especially on fungi. In this study, we Searched data base such as PubMed, Elsevier, Scopus, and Google scholar to have comprehensive review on antimicrobial activity of flavonoids derivatives. Nowadays, it is shown that polyphenols that commonly derived from cereals, herbs and spices have different biological effects on human health, which among polyphenols, increasingly usage of the flavonoids, are becoming the subject of anti- microbial research. Also, optimization of these compounds through structural alteration might lead to development of acceptable antimicrobial agents. Therefore, further studies on other structures of flavonoids as antimicrobial agents is important for progress of control and treatment strategies for infections caused by pathogenic drug resistant bacteria and fungi.

Full-Text [PDF 561 kb]   (121 Downloads)    
Type of Study: Review | Subject: ميکروبيولوژي
Received: 2016/12/14 | Accepted: 2017/05/20 | Published: 2017/05/20

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