Volume 1, Issue 1 (winter 2013)                   Clin Exc 2013, 1(1): 113-128 | Back to browse issues page

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salehifar E. A Review of the Role of Statins in the Treatment of Heart Failure with the Emphasis on the Oxidative Stress . Clin Exc . 2013; 1 (1) :113-128
URL: http://ce.mazums.ac.ir/article-1-31-en.html
Abstract:   (5432 Views)
Cholesterol reduction by statins improves the survival of patients with the atherosclerotic cardiovascular diseases, though serum cholesterol level is normal or borderline. In some studies, statins have been administered to the heart failure patients irrespective of their atherosclerosis state or LDL-levels. Statins may have favorable effects on the oxidative stress and the cardiac remodeling process. Due to the contradictory results of the studies, this review will briefly discuss the role of oxidative stress and inflammation in the heart failure, and then the effects of statins on the inflammatory mediators involved in the heart failure and the clinical trials assigned to the role of statins in the management of heart failure. Finally, considering the methodology of clinical trials, recommendations regarding the use of statins in heart failure patients will be presented.
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Subject: اپيدميولوژي
Received: 2013/01/13 | Accepted: 2013/08/27 | Published: 2013/08/27

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