Volume 14, Issue 3 (11-2024)
Clin Exc 2024, 14(3): 1-10 |
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Darban Razavi E, Lashtoo Aghaee B. Phage Therapy – an alternative to antibiotic therapy of infectious diseases. Clin Exc 2024; 14 (3) :1-10
URL: http://ce.mazums.ac.ir/article-1-851-en.html
URL: http://ce.mazums.ac.ir/article-1-851-en.html
Department of Microbiology, Faculty of medicine, Ramsar Campus, Mazandaran University of medical Sciences, Ramsar, Iran
Abstract: (628 Views)
The emergence of multi-drug resistance pathogenic bacteria and lack of novel antibiotic classes in the past decades have raised serious concerns about the future of infectious diseases control. Since the recognition of antibiotic resistance phenomenon, a wide variety of alternative methods for antibiotic therapy have been proposed. However, due to various limitations, such as fatal side effects or low efficacy in controlling infection, almost none of them gained significant attention. Bacteriophages are the most abundant biological creatures on Earth which target bacterial cells in specific. Their discovery put forward another alternative to antibiotic therapy; bacterial infections could be specifically restricted using phages. Owing to their specificity to prokaryotic cells, no adverse effects will be forced on human cells. Desirable efficacy and absence of adverse effects at the same time, have made “phage therapy” a promising method. In this review, we aimed to gather previously done researches on “phage therapy” and its role in the treatment of antibiotic-resistant infections, to emphasize the efficacy and safety of this method to specialists and researchers. Our suggestion to future researchers is to carry out further structural studies to be able to use phage therapy to combat antibiotic resistance.
Type of Study: Review |
Subject:
عفوني
Received: 2024/09/4 | Accepted: 2024/12/26 | Published: 2024/12/26
Received: 2024/09/4 | Accepted: 2024/12/26 | Published: 2024/12/26
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