Low back pain (LBP) is a major problem in public health. Among the various causes. The back pain is strongly associated with inter-vertebral disc degeneration and the most common disease referred to spine surgeons are lumbar disc herniation (LDH). About 20% of young people have mild symptoms of disc degeneration which gradually increases with age, especially in men. Thus about 60% of seventy years old peoples have sever lumbar disc degeneration. Although most of the symptoms caused by mechanical effect of disc but inflammatory cascade drive from Arachidonic (MMTX, .PGE2,) is another justification for disc pain. The first step in the clinical suspicion to lumbar discopathy is history and careful examination. Any pain in the lower back on a path to lower limbs with dermatomal spread and any weakness and numbness in the lower extremities, especially if happen to be acutely, enhances clinical suspicion. In addition to clinical examination, MRI is an excellent diagnostic tool in the diagnosis of soft tissue lesions and lumbar discopathy. On the other hand, sometimes disc herination alone or with another inflammatory or infectious or neoplastic disorders make different course of manifestation in some patients. Attention to accurate training to medical students and improve the ability to differentiate various differential diagnosis of discopathy can play an important role in the prevention of terrible complications of the disease.